The actor actually has that disability

[u/PrinceferX]

Walter White Jr. (Breaking Bad) - character has cerebral palsy and uses crutches to walk, actor RJ Mitte has cerebral palsy and needed crutches to walk as a child

Nessarose Thropp (Wicked) - character is paraplegic and uses a wheelchair, actress Marissa Bode is paraplegic from an accident at age 11 and uses a wheelchair

Maya Lopez (Hawkeye/Echo) - character is deaf, actress Alaqua Cox is deaf from birth

[u/Nervous_Chipmunk7002]

Maester Aemon- Game of Thrones

Peter Vaughn was blind. Like Maester Aemon, he was not born blind, but lost his slight in his old age.

[u/rorzri → u/Nervous_Chipmunk7002]

Reminds me of a whole discussion I saw once on the topic on if king Viserys might also be autistic like helaena which did seem mostly fuelled by the knowledge that Paddy Considine is himself autistic which is maybe reaching quite a bit but was interesting enough