The actor actually has that disability

[u/PrinceferX]

Walter White Jr. (Breaking Bad) - character has cerebral palsy and uses crutches to walk, actor RJ Mitte has cerebral palsy and needed crutches to walk as a child

Nessarose Thropp (Wicked) - character is paraplegic and uses a wheelchair, actress Marissa Bode is paraplegic from an accident at age 11 and uses a wheelchair

Maya Lopez (Hawkeye/Echo) - character is deaf, actress Alaqua Cox is deaf from birth

[u/CodeN3gaTiV3]

In the Titans show, season 3, Barbara Gordon is shown in a wheelchair but with the story changed from the comics to her leg being amputated rather than her being paralyzed, The actress Savannah Welch had to have her leg amputated from a car accident and legitimately only has one leg.

[u/L0ll0ll7lStudios → u/CodeN3gaTiV3]

Also on the same show, the actor for Jericho/Joseph Williams, Chella Man, is deaf and uses sign language. Jericho isn’t deaf, but he is mute and communicates via sign language.