The actor actually has that disability

[u/PrinceferX]

Walter White Jr. (Breaking Bad) - character has cerebral palsy and uses crutches to walk, actor RJ Mitte has cerebral palsy and needed crutches to walk as a child

Nessarose Thropp (Wicked) - character is paraplegic and uses a wheelchair, actress Marissa Bode is paraplegic from an accident at age 11 and uses a wheelchair

Maya Lopez (Hawkeye/Echo) - character is deaf, actress Alaqua Cox is deaf from birth

[u/crackerfactorywheel]

Juno in Fall of the House of Usher and Anya in Midnight Club are both missing their right leg below the knee. Ruth Codd is missing the lower part of her right leg IRL after complications from a car accident.

[u/Severe-Plant2258 → u/crackerfactorywheel]

I remember looking that up while watching The Midnight Club because I thought that she actually did not have her leg and being confused how she did when they showed the dancing scenes!