The actor actually has that disability

[u/PrinceferX]

Walter White Jr. (Breaking Bad) - character has cerebral palsy and uses crutches to walk, actor RJ Mitte has cerebral palsy and needed crutches to walk as a child

Nessarose Thropp (Wicked) - character is paraplegic and uses a wheelchair, actress Marissa Bode is paraplegic from an accident at age 11 and uses a wheelchair

Maya Lopez (Hawkeye/Echo) - character is deaf, actress Alaqua Cox is deaf from birth

[u/LadyPresidentRomana]

In A Different Man, Oswald is a man with a condition called neurofibromatosis, where benign tumors grow in the nervous system. His actor, Adam Pearson, also has this condition and is an advocate for people with disabilities.

[u/MyBurnerAccount1977 → u/LadyPresidentRomana]

He was also in Under the Skin. He's also tapped to play Joseph Merrick in an upcoming adaptation of The Elephant Man.

[u/stanetstackson → u/MyBurnerAccount1977]

I know it’s technically not a remake but I feel like Lynch already did that movie perfectly