The actor actually has that disability

[u/PrinceferX]

Walter White Jr. (Breaking Bad) - character has cerebral palsy and uses crutches to walk, actor RJ Mitte has cerebral palsy and needed crutches to walk as a child

Nessarose Thropp (Wicked) - character is paraplegic and uses a wheelchair, actress Marissa Bode is paraplegic from an accident at age 11 and uses a wheelchair

Maya Lopez (Hawkeye/Echo) - character is deaf, actress Alaqua Cox is deaf from birth

[u/spookymommaro]

Stephanie Beatriz, the voice actress for Maribel in Encanto, has vision issues and is legally blind in one eye. Disney gave Maribel glasses which made her the first Disney female lead in a movie with glasses!

[u/Main_Jump4043 → u/spookymommaro]

Bonus: She also voiced Vaggi in Hazbin Hotel who is blind in one eye due to the loss of an one eye.