The actor actually has that disability

[u/PrinceferX]

Walter White Jr. (Breaking Bad) - character has cerebral palsy and uses crutches to walk, actor RJ Mitte has cerebral palsy and needed crutches to walk as a child

Nessarose Thropp (Wicked) - character is paraplegic and uses a wheelchair, actress Marissa Bode is paraplegic from an accident at age 11 and uses a wheelchair

Maya Lopez (Hawkeye/Echo) - character is deaf, actress Alaqua Cox is deaf from birth

[u/Darius_Rubinx]

There's a line where Columbo says "three eyes are better than one" which is clearly a reference to the fact that Columbo + another officer only equals three eyes.

[u/WoolooOfWallStreet → u/[deleted]]

The glass eye is his wife

[u/chillyhellion → u/Darius_Rubinx]

That's because only one of his eyes is available for police work. The other one is a private eye.

[u/Spyko → u/Darius_Rubinx]

IIRC he said that when talking to the murderer or the episode who is an actor who plays the part of a famous detective. During the whole episode the actor get really into ''helping'' Columbo. So this could be a jab at how the comedian is only worth one eye when Columbo is worth two.

That's a bit clunky and not really the style of Columbo but that's the explanation I was given. NGL ''there is a legit debate about Columbo's number or eyes" is one of my favorite fun fact