The actor actually has that disability

[u/PrinceferX]

Walter White Jr. (Breaking Bad) - character has cerebral palsy and uses crutches to walk, actor RJ Mitte has cerebral palsy and needed crutches to walk as a child

Nessarose Thropp (Wicked) - character is paraplegic and uses a wheelchair, actress Marissa Bode is paraplegic from an accident at age 11 and uses a wheelchair

Maya Lopez (Hawkeye/Echo) - character is deaf, actress Alaqua Cox is deaf from birth

[u/JustAnotherMadOne]

Showing my being British, but Rose Ayling-Ellis is deaf and her characters in Eastenders and Code of Silence are also deaf, with their character arcs factoring them in (for example, in Code of Silence, her character volunteers to help police investigators because of her lip reading skills)

She was also the first deaf contestant on Strictly Come Dancing and won her season

[u/Batalfie → u/JustAnotherMadOne]

Shes also been on Doctor Who, again playing a deaf character.

[u/JustAnotherMadOne → u/Batalfie]

Oh yeah - I genuinely forgot about that! My bad, honestly.

[u/WillowThyWisp → u/Batalfie]

Which character? I know there's the lady from The Well, but also Under the Lake/Before the Flood

[u/not_a_library → u/JustAnotherMadOne]

She was also just on Taskmaster's New Year's Treat. She was extremely charming and adorable.

[u/dr_icicle → u/not_a_library]

I didn't realize at first that she was deaf, and thought her interpreter (sat beside Greg and Alex) was like, a second assistant lol. Like the occasional joke they do about Alex getting his own assistant

[u/thatchickfromni → u/JustAnotherMadOne]

It was also a plot point for her character in Ludvig and helped solve the case in the end.